The effect of exercise on pancreatic cancer

In Germany, about 20,000 people develop pancreatic cancer each year. The causes of this type of cancer are still not properly understood. A study has now examined the effect of exercise on pancreatic cancer.

The pancreas, also known as the pancreas, is extremely important to the digestive process and is therefore vital. It produces the hormone insulin that regulates sugar and enzymes that help break down food into its components. For example, one of the symptoms of pancreatic cancer can be severe weight loss due to not digesting food properly. Pain in the upper abdomen (between the spleen and liver) can be an indication of problems with the pancreas. Although the causes of this type of cancer are not yet fully known, American researchers have now investigated how exercise affects the disease.

Endurance sports help reduce tumors

Scientists at New York University School of Medicine, along with colleagues at the Mother of Pearl Cancer Center, have made a startling discovery. In a study they led, they found that endurance exercises can reprogram the immune system.1 This leads to a reduction in pancreatic tumors and improved efficacy of immunotherapy, the Science Gateway Genetic Engineering and Biotechnology News reports.2

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The study was initially conducted on mice and then compared with data from cancer patients. Since both mice and humans are mammals, they have an immune system that can recognize and fight foreign invaders (such as bacteria) as well as cancer cells. Says chief scientist Dr. Daphna Bar Saggy.

Even a slight movement shows success

Scientists were surprised to discover that even light exercise can fundamentally change the environment around tumors. Dr. said. Saggy bar.

Interleukin-15 (IL-15) is a so-called cytokine that plays an important role in regulating the immune system. The study found that exercise promotes the survival of IL-15-responsive CD8+ T cells. It even doubled the number of helper T cells found in pancreatic tumors in mice. According to the researchers, other studies have already shown that these T cells are able to kill cancer cells (FITBOOK reported).

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Exercise can reduce cancer rates by 50%

At least in mice, the scientists were able to show that 30 minutes of endurance training five days a week is enough to reduce the rate of cancer formation by 50%. In another experiment, where mice ran a hamster wheel for three weeks, tumor weight was reduced by 25 percent.

The researchers then compared data from cancer patients who participated in another study. These studies showed that patients who exercised before undergoing surgery to remove pancreatic tumors had higher CD8+ T cell counts. As a result, the trained subjects with higher T cell counts were 50 percent more likely to survive the five years. next.

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It is possible to envision new approaches to combating tumors

“Our results show for the first time how aerobic exercise affects the immune microenvironment in pancreatic tumors (…). The work helped demonstrate that activation of IL-15 signaling in pancreatic cancer could be an important therapeutic approach in the future,” explains Dr. Emma Curtis, one of the study’s authors. These results prove once again how important physical activity in general and endurance sports in particular are. It even has a positive effect in the fight against tumors in pancreatic cancer. This may lead to new approaches to fighting cancer in the future.

Sources

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